![]() There is currently no FDA approved therapy for patients with NSCLC harboring HER2 exon 20 insertion mutations.Ī study for poziotinib has been initiated to confirm the clinical benefit seen in Cohort 2, as required for an accelerated approval. The agency has set a PDUFA date of November 24, 2022. The NDA is based on the positive results of Cohort 2 in patients with previously treated locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring HER2 exon 20 insertion mutations. The New Drug Application (NDA) for poziotinib is under active review at the FDA with Fast Track designation. ![]() Poziotinib, a Pan ErbB inhibitor targeting HER2 exon20 mutations The company is working with its partner, Hanmi Pharmaceutical, to support the FDA regulatory review process. Food and Drug Administration (FDA) has accepted Spectrum’s resubmitted Biologics License Application (BLA) for eflapegrastim with a Prescription Drug User Fee Act (PDUFA) date of September 9, 2022. “We are proud of the progress we’ve made toward our core business objectives and we remain dedicated to making a meaningful difference in the lives of cancer patients.” The resubmitted BLA for eflapegrastim was also accepted for review by the FDA,” said Tom Riga, President and Chief Executive Officer of Spectrum Pharmaceuticals. In the first quarter, we initiated a confirmatory study and presented additional positive scientific data for poziotinib. “We anticipate FDA approvals later this year for poziotinib and eflapegrastim. (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, announced today financial results for the three-month period ended Maand provided a corporate update. HENDERSON, Nev.-( BUSINESS WIRE)-Spectrum Pharmaceuticals, Inc.
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![]() You can modify the path to the Python executable in the Interpreter path field. You can choose to enable the automatic uploading of files to the server:Ĭlick Auto-upload files to start uploading on the next save.Ĭlick Sync and auto-upload files to immediately sync the files and upload them on every save in future.Įxpand the list of the available interpreters and click Show All. Mind a notification balloon in the lower-right corner: When you change the project interpreter and select an SSH interpreter, you might need to synchronize the local content with the target server. When P圜harm stops supporting any of the outdated Python versions, the corresponding Python interpreter is marked as unsupported. Then select the desired interpreter in the left pane and click OK. Press Control+Alt+S to open the IDE settings and then select Project | Python Interpreter.Ĭlick the drop-down and select the desired Python interpreter: Switch the Python interpreter in the IDE settings Just click it and select the target interpreter: It is the most convenient and quickest way to switch the Python interpreter. The Python Interpreter selector is located on the status bar. ![]() Switch the Python interpreter using the Python Interpreter selector Configuring an existing Python interpreterĪt any time, you can switch the Python interpreter either by using the Python Interpreter selector or in Settings. Python interpreters can be configured for a new project or for the current project (you can create a new interpreter or use one of the existing interpreters). For example, you can create one virtual environment based on Python 3.6 to develop Django applications and another virtual environment based on the same Python 3.6 to work with scientific libraries. This is helpful when you need to create different virtual environments for developing different types of applications. ![]() You can create several Python interpreters based on the same Python executable. So, before configuring a Python interpreter, you need to ensure that you've downloaded Python and installed it in your system and you're aware of a path to it. When you configure a Python interpreter, you need to specify the path to the Python executable in your system. With P圜harm Professional, you can also configure interpreters to execute your Python code on remote environments by using SSH, Vagrant, Docker, Docker Compose, or WSL (only for Windows). A virtual environment consists of a base interpreter and the installed packages. You can also create a Virtualenv, pipenv, Poetry, or conda virtual environment. You can use a system interpreter that is available with your Python installation. To work with your Python code in P圜harm, you need to configure at least one Python interpreter. ![]() These include the return of Flute Guy, a new game from Sharkmob and Level Infinite, the world premiere of Fortnite's Rocket Racing reveal trailer, and guest presenters like The Muppets' Gonzo and Kratos voice actor Christopher Judge. Geoff Keighley will once again be the host of The Game Awards, and he and the team have already begun teasing some of the big moments and guest stars of the show. Wonder, and The Legend of Zelda: Tears of the Kingdom. Wonder nabbed five.Īs for Game of the Year, it will be a tough battle between Alan Wake 2, Baldur's Gate 3, Marvel's Spider-Man 2, Resident Evil 4 Remake, Super Mario Bros. Marvel's Spider-Man 2 received seven nominations and The Legend of Zelda: Tears of the Kingdom and Super Mario Bros. You can check out the full list of The Game Awards 2023 nominees below, but we can quickly say that Baldur's Gate 3 and Alan Wake 2 are at the head of the pack with 8 nominations each. ![]() That first roundtable will just be first taste of the experience with a second taste happening on December 11 before getting the full course on December 13! What to Expect From The Game Awards 2023Īs we mentioned, The Game Awards is always one of the biggest nights in the video game world as it not only honors the great games and developers of the past year, but it also give fans an exciting look into the future with game announcements, trailers, and reveals. We're also proud to share that, leading up to The Game Awards, we'll have our first roundtable chat with some of the incredible developers behind Alan Wake 2 and Marvel's Spider-Man 2. Here are all of the links where you can watch the stream online: We're hosting the stream for The Game Awards 2023 here, on IGN.com, and on our accounts across all major platforms including YouTube, Twitch, Twitter, and Facebook. We here at IGN will be hosting a pre-show for The Game Awards that takes place at 4pm PT/7pm ET before the official festivities begin, and, as we previously mentioned, we'll be back after the show to break down all the biggest news and reveals from the night! Where to Watch The Game Awards 2023 Online If you live in the GMT or AEST timezones, this translates to 12:30am GMT/10:30am AEST on December 8 for the pre-show and 1am GMT/11am AEST on December 8 as well. The main show will begin at 5pm PT/8pm ET and is expected to run for roughly three hours according to The Game Awards website. The Game Awards 2023 will kick off on December 7 with The Game Awards Opening Act at 4:30pm PT/7:30pm ET. How to Watch The Game Awards 2023 Livestream ![]() Returned in exchange for reimbursement.Returned in exchange for Store Credit, to be used in your next purchase.Exchanged with another item available on Alwaysfashion. Esta nueva temporada, encuentra diseños sofisticados para él.Items that are eligible for return in line with our policy can be: Our customer care specialists will inform you within two business days regarding the final status of your return. The return of an item does not guarantee the acceptance of it by Alwaysfashion. You will be shortly contacted by one of our customer care specialists to assist you with your return.Īlwaysfashion does not bear any responsibility for any problems or mistakes or delays due to items returned without following the above mentioned steps. Once you click the “SUBMIT” button, your return request will reach us. 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Keep reading for the full details and my exact recipe so you can recreate this today!Īffiliate links are included for your convenience. It is equally as delicious as any similar recipe you would get at an expensive coffee shop but free from super yucky ingredients and so much more affordable. I also use my electric kettle to boil the water quickly, but you can boil it any way you choose.īe sure to check out my Amazon Shop for all kinds of recommendations for your kitchen & home.A few weeks ago I shared a Chocolate Frappe recipe that has been a huge hit, so I decided to create an equally as delicious Vanilla Frappe recipe to share with you today! It does use a blender, though, and I absolutely love my Ninja blender. I love how this recipe doesn’t require wild specific tools. A drizzle of chocolate sauce would make a wonderful soft coffee mocha flavor. 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In a blender, combine the instant espresso powder, sugar, and boiling water.Step by Step Instructions for this Blended Homemade Greek Frappe 1 teaspoon Nescafe instant espresso powder.1-2 Tablespoons granulated sugar (adjust the amount for your preference.(For your convenience, a printable recipe card is located at the bottom of this post.) This refreshing iced coffee drink can be made with just a few ingredients & a blender. It’s the ideal refreshment for hot Summer days! You can use a greek frappe mixer or a small electric drink mixer to make this, but I just use my Ninja blender and love how it comes out with small chunks of crushed ice. She served this drink to me in her cozy kitchen and I immediately asked for the recipe.Īs I did some research on this drink, I realized it fits under the definition of a greek frappe as well.īy definition, a greek frappe is instant cofee (like Nescafe), water, ice, and milk mixed together to make a frothy iced coffee drink. I first had this drink when I was visiting a high school friend on a hot Summer day. Step by Step Instructions for this Blended Homemade Greek Frappe. ![]() "Sleepless" is good enough to keep you awake and somewhat engaged, but it isn't impactful enough to keep you up at night thinking about it.Yes! Yes! YES!! Dario Argento returns with the type of film that is worshiped by a select share of real horror fans. The plotting feels like a throwback to genre movies of the late 80s and early 90s and the overall quality is as unremarkable as the corrupt cop tales from earlier in the 2010s. Several plot points in this American version are suspect at best, although the excellent cast helps draw you in and there are a couple decent twists late in the story. This is a remake of the 2011 French thriller "Sleepless Night", but can't match that film's adept storytelling and high tension. "Sleepless" is entertaining, but forgettable and fails to live up to its potential. This leads to a series of escalating confrontations and rising stakes for all involved. All this drama descending upon Rubino's casino is compounded when Bryant and Dennison, who have been following Downs, show up at the casino and work to figure out what's going on. As Downs is trying to hide his son's predicament from the teen's mother, Dena (Gabrielle Union), the person for whom Rubino was transporting the drugs, ruthless local crime boss Robert Novak (Scott McNairy) comes looking for his coke. Rubino sends more masked thugs to kidnap Downs' son, Thomas (Octavius Johnson) and demands that Downs bring the drugs to his casino if he ever wants to see his son again. ![]() Things get dicier when it is revealed that the cocaine that Downs and Cass stole belongs to casino owner Stanley Rubino (Dermot Mulroney). As the story progresses, Bryant becomes convinced that Downs isn't what he seems. ![]() Bryant is also investigating the aforementioned drug murder because shell casings from police ammunition were found at the scene. Bryant's partner, Doug Dennison (David Harbour) and the police psychologist express concern for Bryant's mental and physical state, but she insists on getting back to work. ![]() Meanwhile, in the same department, Internal Affairs detective Jennifer Bryant (Michelle Monaghan) is recovering from a drug bust gone wrong. When their sergeant is assigning a team to investigate the homicide scene, Downs and Cass convince him to give them the case. The movie opens with Las Vegas police partners in crime prevention (and crime), Vincent Downs (Jamie Foxx) and Sean Cass (T.I.) stealing a bag of cocaine from a group of hooded thugs that they unceremoniously dispatch in the process. 2017's "Sleepless" (R, 1:35) has things in common with the corrupt cop movies of the previous decade and those of the 90s. The current decade has given us less popular dirty cop movies like "Rampart" and "The Place Beyond the Pines". In the first decade of the 21st century, we got a chance to enjoy Denzel Washington's Oscar-winning performance in "Training Day", followed by the underrated pair "Cellular" and "16 Blocks" and, of course, the Best Picture Oscar winner "The Departed". As we moved through the 90s, Hollywood served up "Bad Lieutenant", "Unlawful Entry", "Léon: The Professional", "Cop Land" and the Best Picture Oscar nominee "L.A. 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Rearrange, modulate, and customize every aspect of your hybrid ensemble.Īugmented BRASS' simple interface and diverse preset library brings quick results to keep your flow moving - but when you want to get complex, you can. Navigate the exciting sonic territory between each of Augmented BRASS' elements with the central Morph control.īrass that can be transformed, customized, and animated in seconds.Īugmented BRASS is designed to deliver the powerful, authentic brass sounds you need, but give you the flexibility to push your sound into new territory when you need to - in as little time as possible. Augmented BRASS morphs beautifully-recorded samples and powerful synth engines into captivating and refreshing sounds for your composition, production, and sound exploration. Go from evocative chamber trumpets to huge cinematic ensembles, somber melodies to thunderous synth-infused fanfares, essential brass tones to experimental textures unheard - all in the same place. ![]() Augmented BRASS delivers a rich variety of expressive, unique, and powerful brass sounds for modern production and composition, uniting beautifully recorded samples, bold synth engines, and seamless morphing between them. ![]() Advanced SystemCare Pro Crack increases the speed of the system in megabits. By availing a small tool to clear the obsolete data from the system it is incredible. By providing an opportunity to increase the speed of your internet speed online, it is incredible. 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![]() Some people are meant to be individual or independent contributors (ICs) and are exceptionally good at what they do. Just as management isn’t for everyone, being a charge nurse isn’t either. Like being a manager, we shouldn’t necessarily think about becoming a charge nurse as simply as being a logical next step in a career ladder. It will give you insight into all of the decisions and nuances that go into making patient care assignments, difficulty in triaging and balancing admits and discharges, considerations with staffing skill-mix and patient acuity, and thus afford you an overall newfound appreciation for your fellow charge nurses. Bedside Skills of Charge NurseĪdditionally, it will make you a better bedside nurse. You’ll be interacting with a House Supervisor, escalating and coordinating to and with your Nursing Manager more directly, creating communication channels and alignment with other disciplines, and collaborating with fellow charge nurses. You have responsibility in staffing, planning and predicting census, determining appropriate acuity and patient ratios, and representing or advocating for your unit resources. Second, it exposes you to a different aspect of care delivery - from the system and administrative level. There is a different set of leadership skills or competencies that are utilized when in a charge nurse role so you’re stimulated and challenged in a different way. ![]() ![]() The rotating nature of it prevents you from maintaining a single set of responsibilities and skill set, even if your patients and their diagnoses are ever-changing. It’s an incredibly dynamic role, meaning that on any given shift or day, you may be a bedside nurse or a charge nurse. Though it’s certainly not for everyone, there are many benefits of being a charge nurse. Hopefully, they’re always sure to check in, albeit with a smile on their face. They can assuage or de-escalate a patient or family member, help talk you through critical care moments, and often jump in to help before you even have to ask for it. They’re the ones that keep the unit humming, anticipate problems or situations before they arise, and advocate for their clinical nursing staff members and adequate resources. It’s likely that you’ve felt the impact that a great charge nurse can have on a shift. They are often responsible for delegating nursing duties and assignments, coordinating schedules, monitoring admissions and discharges, and overseeing the supply and demand of medications and supplies. What Is a Charge Nurse?Įssentially, a charge nurse is a registered nurse leader that oversees a specific department or unit. One opportunity to do this as a clinical nurse is by becoming a charge nurse and taking up your unit's charge nurse role. It’s important that we continually feel challenged, stimulated, and are making progress in our professional growth. The decision to become a charge nurse is not one to take lightly. |
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